Tibetans at intermediate altitude exhibit lower hemoglobin concentration and distinct responses to poikilocapnic hypoxia relative to Han Chinese residents
نویسندگان
چکیده
منابع مشابه
Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara.
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing relatively low hemoglobin concentration among Tibetan high-altitude natives were unexpected. These suggested a hypothesis of population differences in hematological response to high-altitu...
متن کاملLess is more: blunted responses to hypoxia revealed in sea-level Tibetans.
A DISTINCT SET OF PHYSIOLOGICAL responses (e.g., elevated hemoglobin, ventilation, hypoxic pulmonary vasoconstriction) is elicited in most humans exposed to hypoxia. However, native Tibetans, whose ancestors first inhabited highland regions hundreds of generations ago, exhibit a unique combination of traits associated with their survival above 4,000 m that differs from closely related populatio...
متن کاملTibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia
Tibetan natives have lived on the Tibetan plateau (altitude ∼ 4,000 m) for at least 25,000 years, and as such they are adapted to life and reproduction in a hypoxic environment. Recent studies have identified two genetic loci, EGLN1 and EPAS1, that have undergone natural selection in Tibetans, and further demonstrated an association of EGLN1/EPAS1 genotype with hemoglobin concentration. Both ge...
متن کاملHematological differences during growth among Tibetans and Han Chinese born and raised at high altitude in Qinghai, China.
This study describes the hemoglobin concentration ([Hb]) and hematocrit (HCT) of over 1,000 Tibetan and Han children, adolescents, and young adults who were born and raised at 3,200 m, 3,800 m, or 4,300 m in Qinghai Province, western China. At 3,200 m, no altitude effect is evident in the hematological characteristics of either group. At 3,800 m and 4,300 m, both groups show [Hb] and HCT values...
متن کاملDevelopmental responses to high altitude hypoxia.
From a review of published literature on developmental responses to high altitude, three major conclusions are derived. First, the small birth weight of high altitude native populations are adaptive responses to reduce the oxygen requirements, while the relative increase in the placental weight is a compromise mechanism to increase the volume and surface area €or a better oxygenation. Second, t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.04996